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Here’s the breakdown of what happens in your body to get the blood flowing again:1
Stimulation increases blood flow
Arousal triggers cGMP, a molecule that boosts blood flow to the penis and helps you get an erection.
Limited blood flow stops an erection
In people with ED, an enzyme called PDE5 breaks down cGMP too quickly, reducing blood flow and causing the erection to fade.
Medication promotes a firmer erection
ED treatments block PDE5, helping more blood reach the penis. This leads to firmer, longer-lasting erections.
Reclaim your confidence in the bedroom with clinically proven ED treatments delivered to your door.
Take a simple blood test to uncover what’s really going on.
Speak with our men’s health experts to make a plan that tackles the root cause, not just the symptoms.
Erectile dysfunction is the ongoing inability to get or keep an erection firm enough for sex. It can be caused by physical issues (like poor blood flow, nerve damage, or low testosterone), psychological factors (such as stress or anxiety), or lifestyle habits (like smoking or alcohol use).6
The primary symptom of ED is:6
Inability to achieve or maintain an erection sufficient for penetrative sex.
This may present in various ways, including:
Difficulty achieving an erection at all
Erections that are not firm enough for intercourse
Erections that do not last long enough to complete sexual activity
Loss of erection during foreplay or penetration
Decreased frequency or absence of morning or spontaneous erections
In some men, erection problems come on slowly over time, while for others, they happen quite suddenly. If you’re still getting erections during sleep or when masturbating, it might point to stress or anxiety as the cause. But if things have gradually declined, it could be linked to an underlying health issue like diabetes, heart problems, or hormone changes.6
1. Dhaliwal A, Gupta M. PDE5 inhibitors. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2025.
2. Rabijewski M, Papierska L, Kozakowski J, Zgliczyński W. The high prevalence of testosterone deficiency in population of Polish men over 65 years with erectile dysfunctions. Aging Male [Internet]. 2012;15(4):258–62.
3. Olinic DM, Stanek A. Vascular diseases: Etiologic, diagnostic, prognostic, and therapeutic research. Life (Basel, Switzerland). 2023;13(5).
4. Defeudis G, Mazzilli R, Tenuta M, Rossini G, Zamponi V, Olana S, et al. Erectile dysfunction and diabetes: A melting pot of circumstances and treatments. Diabetes/metabolism research and reviews. 2022;38(2): e3494.
5. Watts M. Diabetes and obesity. Diabetes. https://www.diabetes.co.uk/diabetes-and-obesity.html
6.Leslie SW, Sooriyamoorthy T. Erectile dysfunction. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2025.
7. McMurray JG, Feldman RA, Auerbach SM, Deriesthal H, Wilson N, Multicenter Study Group. Long-term safety and effectiveness of sildenafil citrate in men with erectile dysfunction. Therapeutics and clinical risk management. 2007;3(6): 975–981.
8. Montorsi F, Verheyden B, Meuleman E, Jünemann KP, Moncada I, Valiquette L, et al. Long-term safety and tolerability of tadalafil in the treatment of erectile dysfunction. European urology. 2004;45(3): 339–344; discussion 344-5.
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